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In non-human primates, a second-era nicotine combination referred to as NIC7 demonstrated potential in producing anti-nicotine antibodies, which may lower the drug's concentration within the mind. As a consequence of their capacity to generate excessive-affinity anti-drug IgG antibodies, conjugate vaccines show potential in its place technique of treating drug use disorders. After receiving a vaccination with a conjugate vaccine made from a 6-(carboxymethylurea)-()-nicotine conjugate conjugated with KLH, rats developed antibodies that significantly sure nicotine within the plasma however had no influence on nicotine levels in the mind, limiting the vaccine's potential efficacy.
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