Ultimate carcinogen: It's activated and chemically reactive form of a carcinogen or procarcinogen that's capable of direct covalent binding to nucleic acid or protein macromolecules. IARC considers naphthalene to be a attainable human carcinogen, and NTP considers that it is reasonably anticipated to be a human carcinogen. Kim YD, Lee CH,
Vape Shop Nan HM, Kang JW, Kim H. Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and
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IARC and NTP have classified specific PAH-containing chemical mixtures (e.g., soot, coke oven emissions, coal tars and coal tar pitches) as human carcinogens. The smaller or superb particulates (e.g., PM2.5 or smaller) have higher concentrations of PAHs than the larger or coarse particulates (Bostrom et al., 2002; Rehwagen et al., 2005). Ambient air PAH concentrations present seasonal variation (IPCS, 1998; Rehwagen et al., 2005).
Smoking, grilling, broiling, or other excessive temperature processing results in PAH formation in meat and in other foods, as nicely. Naphthalene is the most considerable PAH in cigarette smoke (Ding et al., 2005),
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