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The research, published in the Journal of Psychopharmacology, is the first study using fMRI (functional magnetic resonance imaging) to gauge how different strains of cannabis impact brain function. The salience network supports other brain networks and determines what sensory or emotional inputs we pay attention to, and disruptions of the network have previously been implicated in addiction and psychosis. There is growing evidence that THC is implicated in addiction and cannabis-induced psychosis. The researchers say their findings add to evidence that cannabis strains with greater CBD content may be less harmful, suggesting that CBD content of cannabis should perhaps be regulated in jurisdictions where it's legal. The findings also provide insight into why CBD holds potential for medicinal uses. CBD has been documented as a potential antiepileptic since 1881; it was approved by the Food and Drug Administration for treating severe types of childhood epilepsy in 2018. However, its anticonvulsant mechanisms are still not fully understood.
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