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The Berkeley Lab information helped Vir determine candidates for further study, and Vir eventually settled on a single candidate antibody, S309. Vir subsidiary Humabs BioMed had already compiled a library of frozen blood samples from patients infected with viral diseases, including two samples from patients infected with SARS-CoV-1. Sotrovimab has demonstrated exercise via two antiviral mechanisms in vitro, antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).

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